What medications are effective for treating the symptoms of gastroparesis?
There is a lack of effective treatments for gastroparesis; those that may be effective are not marketed in many countries. The go-to metoclopramide has weak evidence of a benefit on nausea and bloating but is not effective overall.
Plan de l'etude:
Meta-analysis (randomized controlled trials)
Self-funded or unfunded
These researchers searched 3 databases, including Cochrane CENTRAL, as well as a clinical trials registry, conference proceedings, and reference lists of identified articles to identity 29 randomized controlled trials of treatments for the symptoms of gastroparesis. They included research in any language. Two researchers independently conducted the search, abstracted the articles, and assessed the quality of the research. They used network meta-analysis to compare results of different treatments that were not directly compared. Based on global symptom scores, only clebopride (Clanzoflat, Cleboril), a chemical cousin to metoclopramide, and domperidone were effective to a greater extent than placebo. Clebopride is not widely available and domperidone is not available the United States except as an investigational drug. There was no evidence of publication bias or heterogeneity, but study quality, overall, was low. In a single, small study of 44 patients, metoclopramide had a small effect on nausea and bloating.
Allen F. Shaughnessy, PharmD, MMedEd
Professor of Family Medicine