Children with uncomplicated UTIs treated with 10 days vs 5 days of antibiotics have fewer treatment failures (SCOUT)

Question clinique

Can children with uncomplicated urinary tract infections be successfully treated with short courses of antibiotics?

L’Essentiel

In this study, standard-course therapy for children with UTI was superior to short-course therapy. However, the number needed to treat of 28 suggests that offering short-course therapy is not unreasonable, especially if there is good follow-up in the subsequent weeks. 1b

Plan de l'etude: Randomized controlled trial (double-blinded)

Financement: Government

Cadre: Outpatient (any)

Reviewer

Henry C. Barry, MD, MS
Professor
Michigan State University
East Lansing, MI


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Commentaires

DR ARUP KUMAR DHARA

Impact assessment

Excellent

Anonymous

UNCOMPLICATED UTI IN CHILDRENS

GOOD TO KNOW

Bertus Johannes Reitsma

outcome

N.B.: very high percentage reported for adverse effects !!

Anonymous

No

No

Pieter Richard Verbeek

Short course antibiotic for pediatric UTI

Interesting abstract. I would not have predicted that the absolute difference in treatment failure in the short course group (4.2% failure) would be so "high" compared to the long course group (0.6%). If the goal of treatment is successful eradication of infection then I would think the practice of relying on "good follow up" for short course patients would meet with limited success. This suggestion is worth a follow up study to assess its value.