Low FODMAPS diet is better than an oral spasmolytic for irritable bowel syndrome (NNT = 7 – 9)

Référence

Carbone F, Van den Houte K, Besard L, et al, for the Domino Study Collaborators. Diet or medication in primary care patients with IBS: the DOMINO study - a randomised trial supported by the Belgian Health Care Knowledge Centre (KCE Trials Programme) and the Rome Foundation Research Institute. Gut 2022;71(11):2226-2232.

Sommaire

Both low FODMAPS diets and otilonium bromide (OB) have been shown in randomized trials to have efficacy for the treatment of irritable bowel syndrome (IBS). FODMAPS stands for fermentable oligosaccharides, disaccharides, monosaccharides, and polyols, which are short-chain carbohydrates that are poorly absorbed by some people. This was a pragmatic trial, enrolling primary care patients given a diagnosis of IBS by their physician. Patients with psychiatric comorbidity, who had used a FODMAPS diet, or who had taken OB were excluded. The dietary intervention consisted of an app that provided guidance for a low FODMAPS diet and provided more than 100 recipes; the 40 mg OB intervention was given 3 times daily. Groups were similar at baseline, with a mean age of 41 years, and 76% were female. Analysis was by intention to treat. The primary outcome was a clinically significant improvement of 50 points on the 500-point IBS-Severity Symptom Scale. At 8 weeks, a response was noted by more patients in the FODMAPS group than in the OB group at 4 weeks (62% vs 51%; P = .02; number needed to treat [NNT] = 9) and at 8 weeks (71% vs 61%; P = .03; NNT = 10). The average decline in the score was also significantly higher in the FODMAPS group (-97 vs -77 points; P = .02). There were no differences between groups in overall quality-of-life scales. The authors also prespecified a subgroup analysis of the 309 patients (70%) who met the most recent Rome IV criteria for IBS. The benefit was even greater in these patients in terms of the percentage of responders (77% vs 62%; P = .004; NNT = 7). Adherence was high and was actually better for the diet than for the medication (94% vs 73%).